Abstract: In order to know how familial factors influence college students' mental health in border area minority, this research adopts 16PF, UPI and SCL-90 to investigate College students' mental health status in 9 border areas' minorities by random sampling. The survey results are processed by SPSS13.0 and analyzed by contrast to the self-designed questionnaire's survey findings. The results show that family's general atmosphere, educational mode and member's relationships have outstanding influences on objectives' status of mental health, but neither family's scale, living standard, income, payment capacity for high education nor research objects's numbers of sisters or brothers, seniority among brothers and sisters, status in family have significant influence in the object's psychological health status.