Abstract: The outbreak of COVID-19 posed a threat to the physical and mental health of people around the world. General Secretary XI Jinping emphasized that the work that focused on mental health is of great significance, the whole country should increase investment in psychological counseling and psychological intervention. Under the guidance of relevant departments such as the Department of Ideological and Political Work of the Ministry of Education, colleges and universities organized psychological assistance for college students urgently. However, most college counseling centers have limited counselors, so college instructors who work at the front-line of student management need to do everything possible to offer psychological support for students. This study investigated the emotional and daily-life state, and level of attention to COVID-19 related information of students in a university in Yunnan during the prevention and control of the epidemic. It showed that during the period of epidemic prevention and control, the students ’ negative emotions were at a low level, but more than one-third or even close to half of the students might feel that their life are monotonous and had nothing to do. There were 95.3% of students paid attention to epidemic information through various channels every day, and more than 60% of students spend 1～2 h a day to absorb epidemic-related information. This study explored the core ideas, goals and paths of psychological assistance provided by college instructors for students in different epidemic-risk areas. It aimed to provide theoretical and practical references for the psychological assistance work of college instructors.