Abstract: With the rapid development of China’ s economy and upgrading of China’ s e-commerce, the new pattern of retail business focus on consumers and takes advantage of cloud service capabilities to realize full-scene, all-channel and all-category intelligent marketing pattern, which has an important impact on the development of e-commerce. Combining with the connotation and nature of the new retail, the paper analyzes the problems of Yunnan plateau characteristic agricultural retail in big data application analysis, platform construction, product chain, logistics, quality management and consumption experience, the new retail business pattern of C2S2M (consumer end-supply chain end-production end) was proposed, Yunnan plateau characteristic agricultural products will quickly into the new retail business ecosystem, enhance the market competitiveness.