Abstract: In the era of We Media, information spreads rapidly through the Internet. It is of great significance to discover and guide the network public opinion of university emergencies in time, which can avoid the negative impact in time and effectively. Under the background of big data, based on the massive data of college students’ online behavior, using big data analysis platforms and technologies such as online behavior audit system and behavior perception system, and based on online behavior data, the big data analysis of college emergency network public opinion is carried out in order to achieve the “prior discovery, early warning, in-process prevention, timely response tracing the source after the event” . This paper gives the technical roadmap of network public opinion research and response in colleges and universities, the framework of network public opinion research and response information model in colleges and universities, the construction of network public opinion research and response system in colleges and universities, the strategies of network public opinion response mechanism in colleges and universities, explores the application of Internet technology and information technology to research, judge and early warning of network public opinion in colleges and universities, and feeds back relevant results to member units of the leading group of online public opinion, so as to deal with them in advance. We should make full use of the new generation of information technology to help improve the efficiency of public opinion research and response and the informatization level of ideological and political work. The author’ s research work has reference significance for similar universities in China.