Abstract: According to data of urbanization and ecological environment from 2007 to 2016 in Hexi area of Gansu province, the paper established evaluation index system of urbanization and ecological environment in Hexi area. Through factor analysis, the paper respectively calculated the comprehensive scores of urbanization and ecological environment development in Hexi area, and selected the model of coupling degree and coupling coordinated degree refering to related research. Finally, coupling relationship between urbanization and ecological environment in Hexi region was determined. The results showed that the coupling type of ecological environment and urbanization in most cities in the Hexi Corridor was the lagging type of ecological environment; the degree of coupling coordination between urbanization and ecological environment changed in an “N” shape, among which the coupling degree and coupling coordination degree were on the rise in 2007 to 2009. From 2010 to 2011, the degree of coupling and the degree of coupling coordination were generally in a declining stage. The development of urbanization was gradually accelerating, and the development of the ecological environment was slowing down. The coupling and coordination of urbanization and the ecological environment were in the transitional harmony zone. The degree of coupling and coordination continued to decline from 2012 to 2013. After returning to the dysfunctional recession interval, the urbanization development rate will gradually slow down after 2013, and the level of the ecological environment will gradually increase. The coupling type will increase from a moderately dysfunctional ecological environment lagging type to a well-coordinated ecological environment lagging type. Finally, the paper proposed corresponding countermeasures, such as: establishing a coordinating development mechanism for ecological environment and economic development system; transforming economic development mode, adjusting and optimizing industrial structure, and to promote coordinated regional development; cultivating tourism as a new economic growth point and adhering to the integrated development of ecological environment protection and tourism.