Abstract: Regional economics is a subject to study the combing law of economic activities and space, and it is practical.The article starts with significance of special topic teaching method in teaching of regional economics and it holds that special topic teaching method is in favor of helping students to understand basic theory and knowledge deeply and systematically,helping student to combine theory with practice and apply their knowledge,stimulating the students' learning interests to strengthen class teaching effect.Meanwhile,teacher should prepare teaching content carefully basing on syllabus characterized with typicality and vividness;teacher should select all kinds of teaching methods aiming at student-centered conducting and emphasizing teacher-student interaction; teacher should aim at improve students' professional level to train the ability of analyzing and solving problems by means of optimizing assessment methods to reflect the ability examination.