Abstract: The practice teaching of ideological and political theory course is very important to improve the teaching effectiveness in colleges and universities, but its effect is unsatisfactory in many colleges and universities. In this paper, through an empirical survey of 7 colleges and universities in Yunnan province, it found that the degree of students' satisfaction to the course is low, teaching practice formalism and the imperfect evaluation system result in poor teaching effectiveness. In view of the existing problems, this paper proposes it breaks the original model from the implementation way, content and assessment under the existing resources and conditions to establish a operable comprehensive practical teaching mode, so as to improve the teaching effectiveness of ideological and political theory course.