Abstract: New farmers have become an important force in innovation and entrepreneurship in the field of agriculture, rural areas, and farmers. Exploring the interaction between new farmer entrepreneurship and rural revitalization is of great significance for achieving comprehensive rural revitalization.On the basis of theoretical analysis of the logical relationship between new farmer entrepreneurship and rural revitalization, this study used sample survey data from 512 new farmer entrepreneurship households in Jiangxi, Henan and Anhui provinces, and used entropy method, multi index comprehensive evaluation method and coupling coordination model to empirically examine the degree of coupling between new farmer entrepreneurship and rural revitalization. Research had found that, there was a close logical correlation between new farmer entrepreneurship and rural revitalization. Rural revitalization created conditions for new farmer entrepreneurship in terms of institutional dividends, project platforms, effect accumulation, market demand, talent demand, etc., while new farmer entrepreneurship promoted rural industry prosperity, ecological livability, rural civilization, effective governance, and common prosperity. The coupling and coordination between the entrepreneurial growth performance of new farmers and the level of rural revitalization development in various regions were at a high level, but the coupling coordination level was lower than the coupling level. The entrepreneurial growth performance of new farmers in various regions was relatively synchronized with the development level of rural revitalization, and compared to the entrepreneurial level, rural revitalization lagged behind. To this end, we need to further promote the construction of rural revitalization and create a favorable external environment for new farmers to start their own businesses; strive to improve the entrepreneurial level of new farmers and fully leverage their role in promoting comprehensive rural revitalization; improve the coupling mechanism between new farmers’ entrepreneurship and rural revitalization, and achieve a positive interaction between the two.