Abstract: In the great journey of the new era, the scientific principles in the Communist Manifesto can provide more principled guidance for achieving a better life. The theory of proletarian political parties contained in the Communist Manifesto highlights the greatest political advantage of the Party in leading the entire people to achieve a better life, providing a strong driving force and a benchmark for the construction of a better life in the new era; The profound scientific principles of productivity and relations of production, free and comprehensive development of human beings in the Communist Manifesto reflect the development basis and value pursuit of realizing a better life in the new era; The inevitable trend of history finally moving towards Human history revealed in the Communist Manifesto points out the road choice of building a better life in the new era: In the process of actively complying with the development trend of Human history, we should adhere to the road of Socialism with Chinese characteristics and lead the world to create a better life.