Abstract: In the face of the increasing pressure of resource and environmental constraints, the contradiction between protecting the ecological environment and improving the level of economic development has become a realistic problem faced by Yunnan Province. Taking Yunnan Province as the research area, this paper explored the coupling and coordination of ecological environment and economic development in Yunnan Province from 2010 to 2020 under the constraints of resources and environment based on entropy method and coupling coordination model. The research results show that: the overall comprehensive score of economic system in Yunnan Province from 2010 to 2020 was lower than that of ecological system, and both were at a low level, and the overall coupling degree of the two systems was at a high level, the coordination level fluctuated slightly, but the overall trend was still upward. Therefore, it was proposed to improve the social infrastructure and introduce new and high technologies to speed up urban renewal; perfect the natural ecological environment protection system, strengthen and improve environmental legislation; fully explore the resource advantages and innovate the policy suggestions for tourism development.