Abstract: It’ s the internal requirement for the green development to promote the coordination of the environment protection and high quality development of trade in the Yangtze River Economic Belt. Based on the provincial data from 2010 to 2020, this paper studies the coupling relationship between environment quality and high quality development of trade by entropy method and coordination degree model in the Yangtze River Economic Belt, and uses the spatial auto-correlation model analyzes the degree of spatial dependence of adjacent provinces in the Yangtze River Economic Belt. The results show that:（1）Higher level of coordination of environment quality and high quality development of trade in more economically developed areas.（2）The level of coordination degree in 11 provinces and cities shows a fluctuating upward trend and the Yangtze River Economic Belt as a whole is in a stage of reluctantly coordinated development.（3）The spatial auto-correlation of the coordination degree of environment quality and high quality development of trade is unstable, and the pattern of spatial agglomeration is repeated back and forth between falling and rising, showing the basic pattern of downstream > midstream > upstream in space. It is concluded that the coordinated and rapid development of environment quality and high quality development of trade in the Yangtze River Economic Belt are able to be effectively pushed forward by promoting provincial competition and cooperation,optimizing industrial structure for promote the development of green trade, and giving full play to talent advantages for improving the innovation ability in the future.