Abstract: 105 districts and counties in Anhui Province, the main grain-producing area, were selected as the research areas, and the spatial analysis technology was comprehensively used to analyze the spatial scale changes and temporal intensity changes of facility agricultural land, explore the spatio-temporal evolution law and agglomeration mode of facility agricultural land, and further classify and propose spatial layout difference optimization strategies accordingly. The results show that : （1） In 2005, especially after 2010, the facility agricultural land in Anhui Province spread from the middle to the two sides in space, and gradually showed the distribution of more in the north and less in the south and was mainly concentrated in the north, and the area of facility agricultural land also increased steadily year by year. （2）From 2005 to 2020, the proportion of facility agricultural land in the total area of the land survey in the province showed a rapid growth trend, and the intensity index of change of facility agricultural land in most districts and counties continued to increase, which is generally consistent with the trend of change in the scale of facility agricultural land.（3）After 2010, the facility agricultural land in Anhui Province showed a significant agglomeration characteristic, and the evolution of its spatial autocorrelation state was roughly the same as the evolution of the scale of facility agricultural land.（4）According to the spatial and temporal differentiation characteristics and aggregation mode of facility agricultural land in 105 districts and counties, the province is divided into livestock and poultry breeding areas in the northern Anhui Plain, modern agricultural areas in central Anhui Gangqiu, comprehensive agricultural areas along the yangtze river plain, and comprehensive agricultural tourism areas in the mountainous areas of southwest Anhui, so as to optimize the pattern of facility agricultural land in the province, actively implement and improve the differentiated control measures for facility agricultural land, effectively ensure grain production and safety, and create an excellent environment to meet the needs of facility agricultural land in the main grain-producing areas.