Abstract: Grassroots government is the executor of rural revitalization policy, and farmers are the beneficiaries and participants of rural revitalization. To truly realize rural revitalization, it is necessary to establish a benign interaction mechanism between grassroots governments and farmers. Through case study and empirical analysis, based on the investigation of the administrative staff of the B district street office in Qinhuangdao City and the farmers in 10 villages in the jurisdiction area, it is found that the rigid implementation of the policy of the grass-roots government and the lack of responsibility consciousness of the grass-roots administrative staff lead to the inefficient interaction of the grass-roots government. However, the serious hollowing out of the rural population, the weak awareness of farmers’ interaction and the lack of farmers’ interaction ability make farmers lack of interaction willingness. Therefore, this paper puts forward the countermeasures to optimize the interaction mechanism from five aspects: attaching importance to the cultivation of farmers’ interaction ability, strengthening the responsibility consciousness of grass-roots administrative personnel, implementing grass-roots governance, constructing the interaction platform between grass-roots government and farmers, and improving the evaluation mechanism of grass-roots government.