Abstract: This research applied the UPI university personality inventory and SCL-90 symptom checklist 90 to survey the mental health of ethnic college students who are from nine provinces in frontier regions. The survey was carried out in a random way and followed by a corresponding analysis according to the result of questionnaire with its data processed by SPSS. The results show that: There is a significant impact for the research subjects in terms of their mental health.The impact tightly linked with a various factors, such as to which extend an ethnic group emphasis the importance of education, whether the school provides mental education, what teaching methods applied in the schools or whether the students being hurt in or out of school during the phase of elementary education. Furthering to the college phase, the five indexes, including personal attitude towards college education in one’ s hometown, the time-span of adjusting to college life after entering,the level of satisfaction on identifying oneself during college, estimating one’ s ethnic customs, and having ethnic discrimination or not would influence significantly on one’ s mental health.