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WANG Yi, SHI Hanchao, LIU Wenwen, et al. Acute Toxicity Experiments of 17-methyltestosterone on Mice[J]. JOURNAL OF YUNNAN AGRICULTURAL UNIVERSITY（Natural Science）, 2015, 30(1): 151-153. DOI: 10.16211/j.issn.1004-390X(n).2015.01.026
Citation: WANG Yi, SHI Hanchao, LIU Wenwen, et al. Acute Toxicity Experiments of 17-methyltestosterone on Mice[J]. JOURNAL OF YUNNAN AGRICULTURAL UNIVERSITY（Natural Science）, 2015, 30(1): 151-153. DOI: 10.16211/j.issn.1004-390X(n).2015.01.026
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Acute Toxicity Experiments of 17-methyltestosterone on Mice

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  • Received Date: April 28, 2014
  • Revised Date: June 23, 2014
  • Published Date: January 15, 2015
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  • In order to investigate the safety of 17-methyltestosterone, Kunming mice were tested for its acute toxicity. The absolutely lethal dose (LD100) was determined 4 500.0 mg per kilogram body weight, and the maximum tolerated dose (LD0) was 1 499.7 mg per kilogram body weight in the pre-experiments. In the formal experiment, median lethal dose (LD50) of methyltestosterone in Kunming mice was determined 2 879.7 mg per kilogram body weight, and the 95% confidence limit was 2 522.3 ~3 287.6 mg/kg body weight. According to acute toxicity grading on exogenous chemicals, methyltestosterone has low toxicity in Kunming mice.
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  • [1] LONE K P,MATTY A J. The effect of feeding methyltestosterone on the growth and body composition of common carp (Cyprinus carpio L)[J].. General and Comparative Endocrinology.1980, 40(4):409-424[3]YAMAZAKI F. Application of hormones in fish culture [J].Journal of the Fisheries Research Board of Canada.1976, 33(4):948-958[6] GB 15193.1-2003, 食品安全性毒理学评价程序[S].[7]胡荣,杨忠,魏璐,等. 类固醇和脑功能的研究进展 [J].生理科学进展.2006, 37(1):1-5[9]何映,邱银生,汪辉,等. 体内外急性酒精性肝损伤模型的研究 [J].中国药师.2006, 9(2):115-117
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