Significance of the Clinic and Expression of ED1, CGRP between Operated and Running Exercise to Osteoarthritis Animal Model in Wistar Rats

To investigate the expression of ED1 and calcitonin gene related peptide (CGRP) between the operation and running exercise for deferential osteoarthritis animal model, 45 male Wistar rats were randomly divided into 3 groups:control group (A), operation group (B) and running exercise group (C). The whole knee osteoarthritis of model rats were collected at 1, 2, 3 and 6 weeks and fixed in 4% PFA solution, section, immunohistochemical staining. The expression of ED1, CGRP and the pathological changes of the early osteoarthritis (OA) synovium were observed. Compared with group B, CGRP positive never fibers(7.7530.736), (2.2141.021) to group C was lighter (P0.05);ED1 positive cells expression(401.7715.632), (353.4404.321), (132.3023.447)and(5.5621.201), (18.6651.533), (11.6291.217)significantly higher (P0.01 or 0.05). ED1 positive cells expression in the group B is higher than that in group C;but Running exercise group.CGRP positive never fibers are higher than the operation group.