The Effects of Fermented Pu-erh Tea on the Dynamic Pathological Changes of the Alcoholic Liver Injury Rats

We investigated the effects of fermented Pu-erh tea on dynamic pathological changes of the alcoholic liver injury rats. One hundred and twenty Wistar rats were divided into negative control group, positive control group, drug group, low, medium and high dose of the fermented Pu-erh tea groups. Twenty rats in each group were fed with liquid feed. The low, medium and high dose of the fermented Pu-erh tea were given with daily oral administrations of fermented Pu-erh tea and the doses were 0.5, 1.0, 2.0 g/kg, respectively. The drug group was given with daily oral administrations of drug and the dose was 0.15 g/kg. The negative control group and positive control group were given with oral administrations of 2 mL distilled water. Every 15 days, three rats in every group were randomly selected and the pathological changes of their livers were tested. After 60 days of treatment, all the rats were sacrificed and the liver tissue levels of AST, ALT and pathological changes of the liver were tested. The results showed that compared with the positive control group, the liver levels of AST, ALT in low, medium and high does groups of the fermented Pu-erh tea significantly decreased (P0.01). Through the specimens of rats and pathological detection, it was found that medium and high dose of the fermented Pu-erh tea group obviously improved pathological changes of the liver in alcoholic fatty liver rats. Fermented Pu-erh tea can effectively prevent the occurrence and development of the alcoholic liver injury.