Research on the Effect of Horseradish Leaf Extracts on the Fatigue Resistance, Exercise Endurance and Energy Metabolism in Mice

PurposeTo study the effects of the horseradish leaf extracts on the anti fatigue ability, exercise endurance and energy metabolism ability of mice.

MethodsSixty 4-5 weeks old healthy male mice were randomly divided into blank control group, swimming control group, positive control group, as well as high, medium and low dose groups of horseradish leaf extract, and the rotating rod test and swimming to exhaustion test were performed. The contents of Glu, BUN and Lac in plasma, the contents of glycogen and MDA, and the activities of T-SOD and GSH-Px in tissues were detected.

ResultsThe time of turning rod and swimming to exhaustion in high dose and medium dose groups were significantly higher than that in swimming control group (P<0.05). Compared with the swimming control group and positive control group, the contents of Glu and glycogen, and the activities of T-SOD and GSH-Px in high dose and medium dose groups were increased, while the contents of BUN, Lac and MDA were decreased.

ConclusionThe horseradish leaf extract can improve the anti fatigue ability, exercise endurance and energy metabolism ability of mice in a dose-dependent manner. It is closely related to maintaining the content of Glu and glycogen, increasing the removal rate of BUN and Lac, reducing the content of MDA, and promoting the increase of T-SOD and GSH-Px, etc.