Advanced Search
Xianggui MO, Qin ZHAO, Ken TAN. Identification and Viability Assay of a New Peptide in Venom of Vespa velutina[J]. JOURNAL OF YUNNAN AGRICULTURAL UNIVERSITY（Natural Science）, 2022, 37(1): 126-130. DOI: 10.12101/j.issn.1004-390X(n).202007033
Citation: Xianggui MO, Qin ZHAO, Ken TAN. Identification and Viability Assay of a New Peptide in Venom of Vespa velutina[J]. JOURNAL OF YUNNAN AGRICULTURAL UNIVERSITY（Natural Science）, 2022, 37(1): 126-130. DOI: 10.12101/j.issn.1004-390X(n).202007033
shu

Identification and Viability Assay of a New Peptide in Venom of Vespa velutina

    Graphical Abstract
    • Abstract
  • PurposeTo identify new peptides with biological activity from the venom of Vespa velutina, and lay a foundation for the subsequent development of related drugs.
    MethodsRNA was extracted from the venoms of V. velutina, cDNA library was constructed, and target genes were screened by special primers to identify new peptides and detect their biological activity.
    ResultsThe new peptide was named VV-VP-2. Peptide VV-VP-2 could inhibit Staphylococcus aureus at 100-200 μg/mL and Klebsiella pneumoniae at 50-200 μg/mL. In addition, 5-200 μg/mL VV-VP-2 had an extremely significant scavenging ability on DPPH and ABTS radical (P<0.01or P<0.001), and 50-200 μg/mL VV-VP-2 had an extremely significant scavenging ability on ·OH radical (P<0.01or P<0.001).
    ConclusionThe new peptide found in this study have the potential to be developed as antibacterial and antioxidant drugs, which can lay a foundation for the development of comprehensive drugs or health care products.
    • FullText(HTML)
  • loading
    • References (16)
    • Related Articles

Catalog

    Turn off MathJax
    Article Contents
    Return