Study on Anti-fatigue and Anti-oxidation Effects of Rose Anthocyanin in Mice

PurposeTo study the anti-oxidation and anti-fatigue effects of rose anthocyanins.

MethodsMale healthy Kunming mice were given low (100 mg/kg), medium (150 mg/kg) and high (200 mg/kg) dose rose anthocyanins for 30 days. After weight-bearing swimming, the time of weight-bearing swimming was measured, and the biochemical indexes in serum and liver such as the contents of blood urea nitrogen (BUN), blood lactic acid (BLA) and malondialdehyde (MDA), the activities of lactic dehydrogenase (LDH), glutathione peroxide dismutase (GSH-Px) and total superoxide dismutase (T-SOD), and total anti-oxidant capacity (T-AOC) were measured. According to the linear equation, the relationship between anti-oxidant capacity and anti-fatigue effect of rose anthocyanins was analyzed.

ResultsCompared with the control group, low, medium and high dose of rose anthocyanins extremely significantly prolonged the swimming time of mice with load (P<0.01); the contents of BLA and BUN in the blood of mice with low, medium and high dose of rose anthocyanins significantly decreased (P<0.05 or P<0.01), but the activity of LDH extremely significantly increased (P<0.01); the contents of MDA in the serum and liver of mice with low, medium and high dose of rose anthocyanins decreased, the activities of GSH-Px and T-SOD increased significantly (P<0.05, P<0.01), the T-AOC significantly increased (P<0.05, P<0.01). The correlation analysis showed that with the increase of T-AOC in mice, the contents of BLA and BUN decreased, and the activity of LDH increased.

ConclusionRose anthocyanins can effectively increase the anti-oxidation ability and relieve fatigue, and the anti-oxidation and anti-fatigue effects are dependent on the dose of gavage.