Advanced Search
Huayi BAI, Tingting LIU, Zhuofan DENG, et al. Effects of Restraint Stress on the Hippocampal Synaptic Plasticity in Pregnant Rats[J]. JOURNAL OF YUNNAN AGRICULTURAL UNIVERSITY（Natural Science）, 2021, 36(2): 223-228. DOI: 10.12101/j.issn.1004-390X(n).201911002
Citation: Huayi BAI, Tingting LIU, Zhuofan DENG, et al. Effects of Restraint Stress on the Hippocampal Synaptic Plasticity in Pregnant Rats[J]. JOURNAL OF YUNNAN AGRICULTURAL UNIVERSITY（Natural Science）, 2021, 36(2): 223-228. DOI: 10.12101/j.issn.1004-390X(n).201911002
shu

Effects of Restraint Stress on the Hippocampal Synaptic Plasticity in Pregnant Rats

    Graphical Abstract
    • Abstract
  • PurposeThe neural mechanism of female pregnancy-related mental illness remains unclear. We aimed to investigate the relationship between stress-related pregnancy-induced mental illness and hippocampal synaptic plasticity.
    MethodsAfter restraint stress on rats, in vivo anesthesia electrophysiology was used to detect the excitatory post-synaptic potentials in the hippocampus of rats, and to compare the changes in hippocampal synaptic plasticity in rats undergoing stress and unstressed pregnancy.
    ResultsCompared with the non-pregnant blank control group, the long-term potentiation (LTP) was formed in unstressed pregnant rats induced by low frequency stimulation. In addition, the gestational rats undergoing restraint stress showed no long-term depression (LTD) formation.
    ConclusionStress during pregnancy causes abnormal synaptic plasticity in the hippocampus, which provides important clues for further research on the pathogenesis of pregnancy-related mental diseases.
    • FullText(HTML)
  • loading
    • References (29)
    • Related Articles

Catalog

    Turn off MathJax
    Article Contents
    Return