Effects of Bacitracin Methylene Disalicylate on the Serum and Intestine Antioxidant Indicators of Weaning Rabbits

PurposeIn order to investigate the effect of bacitracin methylene disalicylate on serum and intestine antioxidant indicators in weaning rabbits.

Method300 New Zealand White rabbits were weaned at the age of 35 days, and randomly distributed into five groups according to different diets, there were bacitracin methylene disalicylate high dose group (BMD-H, 100 mg/kg), BMD middle dose group (BMD-M, 50 mg/kg), BDM low dose group (BMD-L, 25 mg/kg), bacitracin zinc control group (BZ, 50 mg/kg), blank control group (BC, no addition). After 35 days of feeding, the antioxidant indicators in the serum and intestine were detected.

ResultThe levels of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in serum and intestine of BMD group and BZ group were significantly higher than those in BC group (P<0.05). The contents of malondialdehyde (MDA) of BMD group and BZ group were significantly lower than BC group (P<0.05), and there were no statistical difference among BMD group and BZ group (P<0.05).

ConclusionThe basal diet supplemented with bacitracin methylene disalicylate could improve the antioxidant function of weaning rabbits, and 100 mg/kg feed additive was the best.