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Mao SUN, Xuewen HE, Jiaqiang DENG, et al. The Effect of Thymol Subinhibitory Concentration on the Secretion of α-Hemolysin in Staphylococcus aureus[J]. JOURNAL OF YUNNAN AGRICULTURAL UNIVERSITY（Natural Science）, 2019, 34(3): 414-419. DOI: 10.12101/j.issn.1004-390X(n).201805007
Citation: Mao SUN, Xuewen HE, Jiaqiang DENG, et al. The Effect of Thymol Subinhibitory Concentration on the Secretion of α-Hemolysin in Staphylococcus aureus[J]. JOURNAL OF YUNNAN AGRICULTURAL UNIVERSITY（Natural Science）, 2019, 34(3): 414-419. DOI: 10.12101/j.issn.1004-390X(n).201805007
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The Effect of Thymol Subinhibitory Concentration on the Secretion of α-Hemolysin in Staphylococcus aureus

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    • Abstract
  • PurposeAlpha-hemolysin (Hla) plays a significant role in the process of Staphylococcus aureus pneumonia. Hla is regarded as a novel target for the treatment of S. aureus infection.
    MethodThe inhibitory effect of thymol against S. aureus Hla was studied via determining the effects of thymol on the growth of S. aureus and hemolysis assay, Western-blot, Real-time PCR and cytotoxicity assay.
    ResultThe MIC of thymol against S. aureus was 256 μg/mL. Thymol can down-regulate the transcriptional levels of hla and RNAIII, inhibited the expression of Hla. Thymol protected A549 cells injure induced by S. aureus Hla.
    ConclusionOur results showed that thymol has the potential to be developed a novel drug for S. aureus pneumonia targeting Hla.
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