Abstract: This article built agricultural quality development evaluation index system from four aspects: agricultural output, agricultural input, rural security and environmental governance, using the entropy right TOPSIS method and tire index objective evaluation of Gansu province high quality agricultural development level and regional differences, using standard deviation ellipse and center of gravity migration model analysis of its 14 cities agricultural quality development trend of time and space. The results showed that, the high quality level of agricultural development in Gansu Province in 2013—2022 was generally low, and the development level of each city decreased with time; the spatial distribution showed “northwest-southeast” trend, and the center of gravity was basically stable in Lanzhou; the differences between regions were obvious, and the differences within the region were stable. In order to realize the high-quality development of agriculture in Gansu Province, we should focus on creating regional characteristics, promoting the coordination between people and land, narrowing regional differences, and building a new pattern of “point with axis and line into surface” , so as to promote the balanced and coordinated development of regional agriculture.